Patrick Wilke and Hans G. Börne
Polyethylene glycol was conjugated with the peptide sequence,
AKPSYPPTYK, which is an adhesive sequence used by mussels. Upon
activation by tyrosinase, the tyrosines in this sequence were converted
into DOPA-quinone allowing the polymer conjugate to adhere to steel as
shown by quartz crystal microbalance measurements. Kinetic experiments
also showed the oxidation of tyrosines in the decapeptide and polymer
conjugated decapeptide by tyrosinase.