Patrick Wilke and Hans G. Börne
Polyethylene glycol was conjugated with the peptide sequence, AKPSYPPTYK, which is an adhesive sequence used by mussels. Upon activation by tyrosinase, the tyrosines in this sequence were converted into DOPA-quinone allowing the polymer conjugate to adhere to steel as shown by quartz crystal microbalance measurements. Kinetic experiments also showed the oxidation of tyrosines in the decapeptide and polymer conjugated decapeptide by tyrosinase.
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