Monday, July 2, 2012

Electron transfer-based combination therapy of cisplatin with tetramethyl-p-phenylenediamine for ovarian, cervical, and lung cancers

 Ting Luo, Jianqing Yu, Jenny Nguyen, Chun-Rong Wang, Robert G. Bristow, David A. Jaffray, Xiao Zhen Zhou, Kun Ping Lu, and Qing-Bin Lu

Combination therapy with cisplatin and N,N,N', N'-tetramethyl-p-phenylenediamine (TMPD) enhanced the mechanism of cisplatin through a dissociative electron transfer reaction as observed by spectroscopic studies and gel electrophoresis. TMPD reduced the dose of cisplatin required. Even in cisplatin resistance human ovarian cells (NIH:OVCAR-3), cancer cells did not survive with cisplatin and TMPD combination treatment.

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