A novel class of antimicrobial cationic polycarbonate/PEG hydrogels were designed and synthesized by Michael addition. These
hydrogels demonstrate strong broad-spectrum anti-microbial activities
against various clinically isolated multidrug-resistant microbes.
Moreover, they exhibit nonfouling properties and prevent the substrate
from microbial adhesion. These antimicrobial and antifouling gels are
promising materials as catheter coatings and wound dressings to prevent