Wednesday, October 24, 2012

Plasmid-Templated Shape Control of Condensed DNA–Block Copolymer Nanoparticles

Advanced Materials

A new method for tuning plasmid DNA nanoparticles by varying solvent polarity during the condensation of DNA with PEG- b -polyphosphoramidate (PPA). Upon separately dissolving the copolymer and plasmid DNA in dimethylformamide (DMF)–water mixtures at fixed volumetric ratios and mixing the two solutions at a predetermined copolymer-to-DNA ratio to achieve effective DNA condensation, a striking variation was observed in morphology.

Thumbnail image of graphical abstract

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