Brady T. Worrell, Jason E. Hein, and Valery V. Fokin
This group demonstrates that 1-iodoalkynes can be clicked with azides to
give 5-iodo-1,2,3-triazoles. With a halogen exchange reaction, the
5-iodotriazole can be converted to a 5-fluorotriazole, which can further
be substituted with a nucleophile to give 1,4,5-substituted triazoles.