Wednesday, October 24, 2012

Halogen Exchange (Halex) Reaction of 5-Iodo-1,2,3-triazoles: Synthesis and Applications of 5-Fluorotriazoles

Brady T. Worrell, Jason E. Hein, and Valery V. Fokin

This group demonstrates that 1-iodoalkynes can be clicked with azides to give 5-iodo-1,2,3-triazoles. With a halogen exchange reaction, the 5-iodotriazole can be converted to a 5-fluorotriazole, which can further be substituted with a nucleophile to give 1,4,5-substituted triazoles.

Thumbnail image of graphical abstract

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