Saturday, October 6, 2012

Ring-Closing Metathesis/Isomerization/Pictet–Spengler Cascade via Ruthenium/Chiral Phosphoric Acid Sequential Catalysis

Ring-Closing Metathesis/Isomerization/Pictet–Spengler Cascade via Ruthenium/Chiral Phosphoric Acid Sequential Catalysis


http://pubs.acs.org/doi/abs/10.1021/ol302215u


Just a nice idea to generate polycyclic frameworks.  The added chiral phosphoric acid (substoichiometric) induces the requisite post-metathesis isomerization and allows the final Pictet-Spengler step to proceed in a highly stereoselective way.


Abstract Image

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