Wednesday, October 24, 2012

NIR-Responsive and Lectin-Binding Doxorubicin-Loaded Nanomedicine from Janus-Type Dendritic PAMAM Amphiphiles

The authors prepare Janus-type dendrimers that self-assemble into micelles. The hydrophilic side contains lactose moieties that promote cell binding and internalization. The hydrophobic side has diazonaphthoqinone groups that undergo a Wolff rearrangement upon near-IR radiation, making the group hydrophilic and promoting micelle disassembly. The micelles were loaded with Dox and shown to release Dox in a controlled fashion.

Abstract Image

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