Saturday, October 6, 2012

Near-Infrared Emitting Radioactive Gold Nanoparticles with Molecular Pharmacokinetic

Chen Zhou, Guiyang Hao, Patrick Thomas, Jinbin Liu, Mengxiao Yu, Shasha Sun, Orhan K. z,
Xiankai Sun, and Jie Zhen

Near-infrared emitting gold nanoparticles were made with the radioisotope 198-Au and were coated with glutathione, which has shown to be a useful surface peptide to reduce uptake by the reticuloendothelial system. The gold nanoparticles were then used to study the pharmacokinetics and biodistribution of gold nanoparticles in mice.  Graph a shows time-activity curves for the gold nanoparticles, which were fit to a two-compartment model to get two half-lives. The short half-life of 5 min. suggest that the Au-NPs could distribute rapidly to tissues, whereas the second half-life of 12.7h was much longer. Figure b shows the % cleared out in the urine after a certain period of time, and suggest that 50% of the Au-NP cleared out by 48 hours. Figure c shows the time activity curves in the liver (black), spleen (red), intestines (green), and kidneys (inset). Figure d shows the biodistribution of the Au-NPs.

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