Chen Zhou, Guiyang Hao, Patrick Thomas, Jinbin Liu, Mengxiao Yu, Shasha Sun, Orhan K. z,
Xiankai Sun, and Jie Zhen
Near-infrared emitting gold nanoparticles were made with the
radioisotope 198-Au and were coated with glutathione, which has shown to
be a useful surface peptide to reduce uptake by the reticuloendothelial
system. The gold nanoparticles were then used to study the
pharmacokinetics and biodistribution of gold nanoparticles in mice.
Graph a shows time-activity curves for the gold nanoparticles, which
were fit to a two-compartment model to get two half-lives. The short
half-life of 5 min. suggest that the Au-NPs could distribute rapidly to
tissues, whereas the second half-life of 12.7h was much longer. Figure b
shows the % cleared out in the urine after a certain period of time,
and suggest that 50% of the Au-NP cleared out by 48 hours. Figure c
shows the time activity curves in the liver (black), spleen (red),
intestines (green), and kidneys (inset). Figure d shows the
biodistribution of the Au-NPs.